Air, road and rail travel affected across Italy on 25 October.
Hundreds of international and domestic flights have been cancelled as part of a 24-hour strike called by Italian trade unions on Friday 25 October.
Alitalia has cancelled 240 flights already while Easyjet says that passengers should expect delays and cancellations.
In addition to air travel, there will be widespread disruption to trains, beginning from 21.00 on Thursday 24 October.
Rail services will be guaranteed however between the rush-hour times of 06.00-09.00 and 18.00-21.00 on 25 October.
Rome will be particularly badly hit on Friday with a massive general strike involving up to 30,000 employees of the city's 18 municipal companies.
The strike will affect all public transport operated by ATAC, including bus and metro, with two strike actions involving members of various trade unions: one for 24 hours and one from 20.00 until midnight. In the case of the 24-hour strike, Rome's public transport will be guaranteed until 08.30 and from 17.00 until 20.00. In other words, don't expect buses and metro to be running between 08.30 and 17.00.
The city's bins will not be emptied by waste collection company AMA which has urged Rome residents to keep their trash at home.
The strike will also hit the capital's public kindergartens and schools, as well as many other sectors including museums, libraries, city offices and social services.