Recurring 'miracle' occurred at precisely 17.59 after a day of intense prayer.
The blood of Naples' patron saint Gennaro liquefied at the city's cathedral on Thursday evening, leading to relief among some superstitious Neapolitans who see it as a good omen.
The 'miracle' traditionally occurs on three dates: 19 September (the saint's feast day), 16 December and the first Saturday in May.
On each occasion the faithful gather in the southern Italian city to witness the liquefaction of what is claimed to be a sample of S. Gennaro's blood, kept in a sealed glass ampoule.
Three times a year this vial of dried blood is exposed for public veneration, with the "relatives" of S. Gennaro - a group of elderly faithful - chanting litanies and prayers in a tradition dating back to the 19th century.
Who was S. Gennaro?
S. Gennaro, or St Januarius, was a bishop of Benevento in the third century, whose bones and blood are preserved as relics at the cathedral in Naples.
He is believed to have been martyred during the Christian persecution, under Emperor Diocletian, circa 305.
According to local lore, if the blood of S. Gennaro fails to liquefy it signals imminent disaster including war, famine or disease.
The miracle occurred in May of this year and again in September, however the blood failed to liquefy on 16 December 2020, in what was seen by some as an omen of bad things to come.
Superstitious Neapolitans believe it is a worse omen however if the miracle does not occur on the saint's feast day.
Two months after the blood failed to liquefy on 19 September 1980, Irpinia - located 50 km east of Naples - was hit with a devastating earthquake that killed almost 3,000 people.
On previous - but not all - occasions when the blood failed to liquefy on the saint's feast day, it signalled bad news for Naples.
The miracle also did not occur in 1939 and 1940, coinciding with the beginning of world war two and Italy's entry into the conflict, and again in September 1943: the date of the Nazi occupation.
Neapolitans have always turned to their patron to protect them from natural disasters - writes the Italian bishops' newspaper Avvenire - with crowds of people in the early centuries seeking refuge in the catacombs of Capodimonte.
So it happened in 472, 512 and 685, with the Neapolitan bishops of the time leading the prayers of the people.
It then became customary to invoke S. Gennaro to ask for an end to volcanic eruptions: in 1631, on 16 December, it was decided to exhibit the relics and the eruption of Vesuvius stopped.
The Catholic Church has always supported the celebrations but has never formulated an official statement on the 'miracle'.
However it does not permit the sealed vial to be opened which has hampered scientific research into the phenomenon.
The blood did not melt during the visits of Pope John Paul II in 1990 or Pope Benedict XVI in October 2007 - reports Avvenire - however it did liquefy when Pope Francis visited in March 2015.
View on Map
Italy 'miracle' as blood of Naples saint liquefies
Via Duomo, 147, 80138 Napoli NA, Italy