The absence of the 35-year-old Parisse, the most capped player in Italian rugby history, is seen as a major blow to Italy's team whose coach is Irishman Conor O'Shea.
Six Nations ticket-holders will have free admission to 16 Rome museums throughout the weekend, thanks to the IV Tempo Rugby e Cultura initiative.
For those who wish to watch the weekend's rugby games on the big screen, check out our list of top venues in Rome.
Italy's third and final home game in the 2019 Six Nations will be against France on 16 March.
For full details see Six Nations website.
Address Viale dei Gladiatori, 00135 Roma RM, Italia
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Irish rugby fans in Rome for Six Nations
Viale dei Gladiatori, 00135 Roma RM, Italia
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